The mechanism leading to this risk is unknown. Escitalopram is contraindicated in patients with known QT-interval prolongation or congenital long QT syndrome. Escitalopram may be started 14 days after discontinuing treatment with the an irreversible MAOI. In addition, a number of side effects are known to occur in relation to medicines that work in the same way as escitalopram the active substance in Losiram. Polymorphism It has been observed that poor metabolisers with respect to CYP2C19 have twice as high a plasma concentration of escitalopram as extensive metabolisers. Escitalopram is a selective inhibitor of serotonin 5-HT reuptake with high affinity for the primary binding site. Healthcare professionals are asked to report any suspected adverse reactions via Yellow Card Scheme at:

You should also be aware that patients under the age of 18 years are at increased risk for side effects, such as suicidal tendencies, suicidal ideation and hostility predominantly aggressiveness, oppositional behavior and anger when using drugs in this class. Studies in animals have shown that citalopram, a drug similar to escitalopram, reduces the quality of sperm. After stopping Losiram, you must allow it to pass 7 days before using any of these medicines. Concomitant treatment with non-selective, irreversible monoamine oxidase inhibitors MAO-inhibitors is contraindicated due to the risk of serotonin syndrome with agitation, tremor, hyperthermia etc. The drug can be used for a single troubling symptom or a life-threatening condition. The dose may be increased by your doctor to a maximum of 20 mg a day. As improvement may not occur during the first few weeks or more of treatment, patients should be closely monitored until such improvement occurs. Your doctor will probably check your blood clotting time when it starts or stops Losiram treatment to check if your anticoagulant dose remains appropriate.


Clinical data on escitalopram overdose are limited and many cases involve concomitant overdoses of other drugs. While it is difficult to know the precise risk of sexual dysfunction associated with the use of SSRIs, physicians should routinely inquire about such possible side effects. Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.


If you losirak such symptoms, talk to your doctor. In addition to the above mentioned adverse reactions, the following were reported: This site does not supply any medicines. Take Losiram solution by mouth with or without food.

Bilim Pharmaceuticals

Bruxism, agitation, nervousness, panic attack, confusional state. John’s Wort Hypericum perforatum may result in an increased incidence of adverse reactions see section 4. However, the exact mechanism of cardiotoxicity in rats is not clear.

The dose may be increased by your doctor to 10 mg a day. Adults Safety of daily doses above 20 mg has not been demonstrated.

In case gilm do not feel better or if you feel unwell, you should talk to a doctor. Losiram, the S-enantiomer of losiam, belongs to a class of antidepressant agents known as selective serotonin-reuptake inhibitors SSRIs. Concomitant use of non-steroidal anti-inflammatory drugs NSAIDs may increase bleeding-tendency see section 4.

Further information on drug naming conventions: Reversible, selective MAO-A inhibitor moclobemide. The incidence of bradycardic outliers was 0. SSRIs should be avoided in patients with unstable epilepsy, and patients with controlled epilepsy should be closely monitored.

SSRIs should be discontinued in any patient entering a manic phase. When using during the last three months of pregnancy, medicines such as Losiram may increase the risk of a severe disease in newborns, called congenital lung hypertension HPPNcausing the newborn to breathe more quickly and appear to grow. How losirak store Losiram: Gastric loslram and the use of activated charcoal should be considered. Clinical efficacy Major depressive episodes Escitalopram has been found to be effective in the acute treatment of major depressive episodes in three out of four double-blind, placebo-controlled short-term 8 weeks studies.


Epidemiological data have suggested that the use of SSRIs in pregnancy, particularly in late pregnancy, may increase the risk of persistent pulmonary hypertension in the newborn PPHN. If you take more Losiram than the prescribed dose, contact your doctor or emergency department of the nearest hospital immediately.

LOSIRAM (ESCITALOPRAM) 20 mg. №28 tablets

Escitalopram is contraindicated in patients with known QT-interval prolongation or congenital long QT syndrome. Duration of treatment It may take several weeks before you feel better. Bilim Pharmaceuticals Product Code: Escitalopram is contraindicated in combination with non-selective irreversible MAOIs.

Patients receiving oral anticoagulant therapy should receive careful coagulation monitoring when Losiram is started or stopped.


SSRIs can lower the seizure threshold. Musculoskeletal and Connective Tissue Disorders: Reduced renal function Dosage adjustment is not necessary in patients with mild or moderate renal impairment. Close supervision of patients and in particular those at high risk should accompany drug therapy especially in early treatment and following dose changes.

However, you may have a relapse of depression if you stop taking your antidepressant. Cimetidine and omeprazole used in the treatment of gastric ulcerfluvoxamine antidepressant and ticlopidine used to reduce the risk of stroke.